Day 1 :
Keynote Forum
Aharon Gedanken
Stanford Bar-Ilan University, Israel
Keynote: Making the hospital a safer place by the sonochemical coating of all its textiles with antibacterial nanoparticles
Time : 10:00 am - 10:45 am
Biography:
Aharon Gedanken has obtained his Ph. D. From Tel-Aviv University. He has published more than 880 papers in reputed journals and his H-Index is 98 according to the Web of Science and 110 according to Google Scholar. He has been serving as an editorial board member of 8 Journals. He was the Israeli representative in the NMP committee of the European FP7 program. He served as the chairman of the Chemistry Department and the Dean of the Faculty of Exact Science. He was awarde prizes of Israeli Chemical Society and the Israeli Vacuum Sociaty for Excellence in Research.
Abstract:
A sonochemical method was developed for coating surfaces. It was applied to coat metals, ceramics, polymers. Glasses, textiles and even paper. It demonstrated that a large variety of properties can be imparted to the substrate. It can make the surface magnetic, conductive, fluorescent, antibacterial, and antiviral. As far as coating textiles it is considered the best coating technique since cotton coated with CuO nanoparticles that was washed 65 cycles in Hospital washing machines (75 or 92 0C) revealed 83 % of the particles on the cotton at the end of this long process1. For making textiles antibacterial we employed ZnO, CuO, and Zn0.11Cu0.89O as the coated layer on the textiles (cotton, Polyester, Nylon and their mixtures). The killing mechanism of the bacteria was due to the creation of ROSs. Hydroxyl radicals, superoxide anions, and singlet oxygen were detected as a result of the reaction of the metal oxide with water. This coating technique was applied to medical devices as well. Contact lenses, Urinal Catheters and Cochlear electrodes were all coated with metal oxide nanoparticles and exhibited excellent antibacterial properties. It is worth mentioning that we own two sonochemical roll to roll coating machines and are attempting to introduce in the market new face masks. Finally, the SONO MASK that is currently being sold all over the market is a demonstration of a technique that has gone all the way from the laboratory to the market.
Keynote Forum
Rossana Migheli
University of Sassari, Italy
Keynote: The genistein by loading into transfersomes as new possible adjuvant in the oxidative stressrelated neurodegenerative diseases
Time : 10:45 am - 11:30 am
Biography:
Rossana Migheli has completed his PhD in 1995 from Sassari University and postdoctoral studies from Sassari University School of Medicine. She is a researcher in Sassari University School of Medicine directs the cellular laboratory of Pharmacology. She has published more than 50 papers in reputed journals. The your research in recent years has mainly concerned the neurochemistry of natural and synthetic antioxidant molecules in neuronal models in vitro and in vivo of oxidative stress. She used different technologies in order to evaluate new strategies for the administration of drug therapies.
Abstract:
Genistein (GEN) is a soy-derived isoflavone, and its antioxidant and neuroprotective activity has been reported by several authors. Promising results have been obtained both in vitro and in vivo studies, but several drawbacks such as low oral bioavailability, poor water solubility, and rapid metabolism/excretion limit GEN’s clinical applications. The aim of this study was to overcome those limitations by loading GEN in transferosomes (GEN-TF) and use GEN-TF as a potential therapeutic or preventive strategy in neurodegenerative diseases. Several GEN-TF complexes were administered and tested on H2O2-induced oxidative damage in PC12 cell line by means of MTT, LDH and flow cytometer assay. All the obtained genistein carrier were able to improve GEN internalization in PC12 cells, reducing ROS and the amounts of apoptotic cells generated by H2O2 treatment, strengthening the neuroprotective activity of GEN. The experimental data indicate the GEN-TF2 as the most promising drug delivery system in terms of antioxidant activity and oxidative stress reduction in our PC12 cells model. These results suggest that GEN-TF2 could be used as adjuvant therapy in oxidative stress-related neurodegenerative diseases.
- Biomedicine | Medical Devices | Biomedical model | Biomedical Science | Computational Biomedicine | Personalised medicine | Pharmacotherapy | Biopharmaceutics
Location: webinar
Session Introduction
Wan Rosli W. I
Universiti Sains Malaysia Health Campus, Malaysia
Title: Does polyphenolic-rich fraction of cornsilk (stigma maydis) exhibits anti-hyperglycaemic properties in streptozotocin-induced diabetic rats?
Time : 12:00 pm - 12:30 pm
Biography:
Abstract:
Diabetes mellitus DM) is an impairing chronic metabolic disorder associated with high blood glucose levels (hyperglycaemia) mainly due to insulin insensitivity. Polyphenols are known as potent compounds that able are to prevent the prevalence of diabetes. The present study was aimed to investigate in vivo anti-hyperglycaemic activity of a phenolic-rich fraction (PRF) of cornsilk and to characterize its principal constituents. The bioactive compounds in PRF were analyzed using the liquid chromatography-mass spectrometry/quadrupole time-of-flight (LC-MS/QTOF) system. The antioxidative potentials and antihyperglycaemic properties of PRF were subsequently evaluated by using in vivo methods in streptozotocin (STZ)-induced diabetic rats. Cornsilk extract was obtained using 40% ethanol, then sequentially fractionated into n-hexane, ethyl acetate and aqueous fractions. These fractions were used to evaluate the antioxidant capacities and to investigate protective effects on high glucose toxicity using human umbilical vein endothelial cells (HUVEC) as endothelial cell models via MTT assay. Results show that the ethyl acetate fraction had the highest antioxidant capacities. The PRF was found to be nontoxic to HUVEC. A high concentration of glucose (30 mM) treatment significantly induced HUVEC death, but PRF significantly restored the viability of HUVEC in a dose-dependent manner, compared to control. The LC-MS/QTOF analysis of PRF reveals the presence of 26 polyphenolic compounds and flavonoids being the major constituents. Flavonols, flavones, flavanols, flavone C-glycosides, flavonol O-glycosides, and isoflavonoids are the subgroups of flavonoids detected in the PRF. Flavanols were the major group of flavonoids detected in this PRF. Treatment of diabetic male rats with PRF at 100 and 200 mg/kg doses for 28 days significantly decreases blood glucose levels in diabetic rats. In brief, PRF could improve glycaemic control in diabetic rats which has a beneficial effect in correcting hyperglycaemia and preventing diabetic-related complications.
Rajendrakumar V. Sarf
Chairman Viraj Paryavarn Prashala, India
Title: Covid paendemic and its impact on water and wastewater treatment plant
Time : 12:30 pm - 1:00 pm
Biography:
Rajendrakumar V. Sarf is serving as Chairman of Viraj Envirozing India Pvt. Ltd, Pune, India. He published 82 Papers in Indian & International Journal. More than 15 Articles published in news Paper. More than 60 students completed Research Project for their Master Degree, Participated as Guest Speaker, Chairman and active participants in many technical seminars, workshops, conferences in India & abroad. Organized workshops, seminars & conferences on State, National & International levels. He has forty Six years of Experience in the Field of Environmental Control Technology and also received Patent for Deep Tank Aeration System.
Abstract:
Current evidence indicates that the COVID-19 virus is transmitted through respiratory droplets or contact. Contact transmission occurs when contaminated hands touch the mucosa of the mouth, nose, or eyes; the virus can also be transferred from one surface to another by contaminated hands, which facilitates indirect contact transmission. Consequently, hand hygiene is extremely important to prevent the spread of the COVID-19 virus. The COVID-19 virus has not been detected in drinking water. Conventional water treatment methods use Aeration, flocculation, sedimentation, filtration and disinfection. The entry of COVID-19 Virus is likely by washing the hand. When the hand is washed the lipid cover on the virus is washed away resulting in total kill of virus. COVID-19 virus has been detected in the feces of some patients diagnosed with COVID-19. However, the quantity of virus released from the body, how long it will be released from the body after infection & whether the virus in the stool is infectious are not yet known. The risk is expected to be low based on data from previous outbreaks of related corona viruses, such as severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS). There have been no reports of fecaloral transmission of COVID-19 to date. The risk of transmission of the virus that causes COVID-19 through sewerage systems is thought to be low. Till date there is no evidence that this has occurred. In the 2003 SARS outbreak, Standard municipal wastewater system chlorination practices are sufficient to inactivate corona viruses, as long as utilities monitor free available chlorine during treatment to ensure it has not been depleted. Waste water treatment consists of Preliminary, Primary & Secondary treatment. Tertiary treatment is used where water is to be recycled. Removal of virus along with flocculated suspended solids cannot be ruled out. Aerosols are generated both in water & waste water treatment plants. This paper critically evaluates the effect of various treatment units of water & wastewater treatment plants on removal of Covid 19 and risk associated with the workers and end users of the finished product from the water & wastewater treatment plant.